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| 16 | Fri, 05/21/2010* | 7:00 PM | West Gadsden High School | West Gadsden | Florida High Seminoles | 0 - 34 | box |
| 17 | Fri, 09/03/2010 | 7:00 PM | Florida High Field | Florida High Seminoles | FAMU High | | |
| 18 | Fri, 09/10/2010 | 7:00 PM | P.K. Yonge | P.K. Yonge | Florida High Seminoles | | |
| 19 | Fri, 09/17/2010 | 7:00 PM | Florida High Field | Florida High Seminoles | Lincoln | | |
| 20 | Fri, 09/24/2010 | 7:00 PM | East Gadsden High School | East Gadsden | Florida High Seminoles | | |
| 21 | Fri, 10/01/2010 | 7:00 PM | Florida High Field | Florida High Seminoles | Wakulla | | |
| 22 | Fri, 10/08/2010 | 7:00 PM | Florida High Field | Florida High Seminoles | Fort White | | |
| 23 | Fri, 10/22/2010 | 7:00 PM | Bradford High School | Bradford | Florida High Seminoles | | |
| 24 | Fri, 10/29/2010 | 7:00 PM | Florida High Field | Florida High Seminoles | Union County | | |
| 25 | Fri, 11/05/2010 | 7:00 PM | Florida High Field | Florida High Seminoles | Taylor County | | |
| 26 | Fri, 11/12/2010 | 7:00 PM | West Gadsden High School | West Gadsden | Florida High Seminoles | | |
| * exhibition, ** playoff, *** make-up |
|
